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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP3A5
All Species:
21.21
Human Site:
S281
Identified Species:
77.78
UniProt:
P20815
Number Species:
6
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P20815
NP_000768.1
502
57109
S281
L
M
I
D
S
Q
N
S
K
E
T
E
S
H
K
Chimpanzee
Pan troglodytes
NP_001087246
502
57138
S281
L
M
I
D
S
Q
N
S
K
E
T
E
S
H
K
Rhesus Macaque
Macaca mulatta
NP_001035309
503
57364
S281
L
M
I
D
S
Q
N
S
K
E
T
E
S
H
K
Dog
Lupus familis
XP_536868
503
57605
S281
L
M
I
N
S
Q
N
S
K
E
T
D
T
H
K
Cat
Felis silvestris
Mouse
Mus musculus
Q64464
503
57474
Y281
L
M
I
N
S
Q
N
Y
K
T
K
E
S
H
K
Rat
Rattus norvegicus
P51538
503
57793
S281
L
M
I
N
S
Q
N
S
K
V
K
D
S
H
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VG82
516
60260
K293
R
G
I
I
Q
T
E
K
T
K
A
S
A
V
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
91.2
79.1
N.A.
74.3
74.9
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
N.A.
Protein Similarity:
100
99.8
95.2
89.6
N.A.
87.6
87.8
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
54.4
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
80
N.A.
73.3
73.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
80
86.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
15
0
15
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
43
0
0
0
0
0
0
0
29
0
0
0
% D
% Glu:
0
0
0
0
0
0
15
0
0
58
0
58
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
15
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
86
0
% H
% Ile:
0
0
100
15
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
15
86
15
29
0
0
0
86
% K
% Leu:
86
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
86
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
43
0
0
86
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
15
86
0
0
0
0
0
0
0
0
0
% Q
% Arg:
15
0
0
0
0
0
0
0
0
0
0
0
0
0
15
% R
% Ser:
0
0
0
0
86
0
0
72
0
0
0
15
72
0
0
% S
% Thr:
0
0
0
0
0
15
0
0
15
15
58
0
15
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
15
0
0
0
15
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
15
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _